Zwijnaarde, Belgium

Bio-Analysis

Confo Therapeutics is the only GPCR company with a discovery engine that precisely targets desired GPCR conformations. This unique capability allows us to unlock a vast untapped potential for the discovery and development of breakthrough medicines. We are advancing a robust pipeline of large and small molecules focused on validated targets in endocrine and metabolic diseases, as well as addressing a broader array of critical unmet medical needs in collaboration with our partners. Our team of approximately 60 people is dedicated to advancing our technology, expanding our capabilities, and building out our pipeline in order to achieve the best possible therapeutic outcomes for patients.

Confo Therapeutics is located on the Technology Park in Ghent. More information about Confo’s technology and strategy can be found on www.confotherapeutics.com.

For the expansion of our R&D team we are currently looking for a
(Senior) Scientist, Discovery Pharmacology.

This role requires significant expertise in in vivo drug profiling and pharmacokinetics (DMPK) sciences, offering a unique opportunity for the successful candidate to play a pivotal part in discovering and developing new therapeutics for endocrine and metabolic diseases.

Key Responsibilities

• Design, plan, and supervise in vivo PK and preclinical studies promptly to advance drug molecules (small molecule and antibody) across various indications within endocrine and metabolic diseases.

• Develop and lead DMPK, modeling, and simulation strategies to support the progression of drug candidates (small molecule and antibody) from discovery through development.

• Collaborate closely with other departments (biology, chemistry, bioanalysis, screening, clinical development, etc.) and external partners (CROs) to align objectives and produce meaningful DMPK and in vivo efficacy data that guide target validation, compound characterization, and candidate selection.

• Conduct quality control analyses on in vivo and DMPK data generated by CROs.

• Analyze, interpret, and clearly communicate DMPK data, provide expert opinions, and support project decision-making to ensure pipeline progress.

• Stay informed about advances in DMPK research and integrate new concepts as appropriate.

• PhD (or equivalent) in Pharmacology, Biomedical Sciences, or a related field, plus at least four years of industry experience.

• Possess a deep understanding of drug metabolism, distribution, and excretion; experience with both small molecules and antibodies is advantageous.

• Extensive background in preclinical and clinical DMPK in an industrial setting, with a proven record of scientific accomplishments.

• Comprehensive knowledge of ADME sciences, drug metabolism, pharmacokinetics, bioanalysis, PKPD principles, human PK, and familiarity with industry-standard software.

• Experience with various therapeutic modalities is considered a strong asset.

• Outstanding communication and presentation abilities.

• Strong leadership skills, with the capacity to influence others and make decisions.

• Proven ability to work effectively in a matrix environment, manage multiple projects, and handle shifting priorities.

Zwijnaarde, Belgium

Biologics Discovery

Confo Therapeutics is the only GPCR company with a discovery engine that precisely targets desired GPCR conformations. This unique capability allows us to unlock a vast untapped potential for the discovery and development of breakthrough medicines. We are advancing a robust pipeline of large and small molecules focused on validated targets in endocrine and metabolic diseases, as well as addressing a broader array of critical unmet medical needs in collaboration with our partners. Our team of approximately 60 people is dedicated to advancing our technology, expanding our capabilities, and building out our pipeline in order to achieve the best possible therapeutic outcomes for patients.

Confo Therapeutics is located on the Technology Park in Ghent. More information about Confo’s technology and strategy can be found on www.confotherapeutics.com.

For the expansion of our Biologics Discovery team we are currently looking for a
(Jr) Research Associate - Biologics Discovery.
This is a temporary 6 month contract with possibility of becoming permanent.

The chosen candidate will integrate a collaborative team that is responsible for the screening and selection of lead panels of functional biologics.

Your responsibilities

 The successful candidate may have the following responsibilities:

• Maintenance of mammalian cell cultures

• Express membrane proteins in mammalian cells using a variety of transfection methods.

• Characterize antibodies using a range of cell-based assays to assess their functionality.

• Careful documentation of experimental work, provide high-quality data on time and report results within electronic lab notebook

• Prepare and effectively present your experimental results (written and oral) to project teams

• Help maintaining laboratory equipment and inventory levels for laboratory supply

Our preferred candidate will have the following profile:

• Bachelor’s or Master’s Degree in Life Sciences or equivalent.

• Bench oriented and preferentially trained in an industry environment (biotech or pharma).

• Experience with molecular biology and/or flow cytometry is a plus .

• Direct experience with mammalian cell culturing and transient transfections is an asset.

• Embrace the company’s “one team, one mission” approach through fostering a culture of teamwork, collaborating effectively across teams in a growing company

• Fluent communication skills in English, both written and verbal.

• Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timeliness are essential

Our offer

• A competitive compensation package with extensive benefits

• A job where you can make the difference

• An entrepreneurial and stimulating working environment in a growing and ambitious biotech company

Zwijnaarde, Belgium

Didn’t find what you are looking for, but our website has sparked your interest?

We are always looking for great talent, and we would love to hear from you.

Please submit your CV/resume and a covering letter explaining why you are interested in joining Confo Therapeutics.